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The LR3 in the name is what sets this variant apart
13 When comparing the active GLP-2R structure with the GLP-1-bound GLP-1R structure, 13 the extracellular end of TM1 in GLP-2R is extended by six additional residues, thereby bending toward GLP-2 with the formation of additional hydrogen bond and hydrophobic contacts
Chan AKY
doi: 10.1124/jpet.114.218735
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Semaglutide GLP-1 is administered via subcutaneous injection, typically once a week, irrespective of meals
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