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These initial studies reported increased NAD + and NAM levels in plasma, and in urine, the excreted NAD + levels increased after 6 h 66 , but it must be noted that these trials utilized small cohorts and short testing periods, and only a minor trend for cognitive improvement was observed 117

These factors lead to an easier buildup of free radicals and accumulation of toxins, which the body copes with with its natural first line of defense of antioxidants, which often may not be sufficient

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