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It enrolled adults with a body mass index of 30 or greater, or 27 or greater with at least one weight-related comorbidity, and randomized them across multiple retatrutide dose arms (1 mg, 4 mg, 8 mg, and 12 mg weekly) versus placebo
reported elevated GLP-1 levels in individuals with sarcopenia, and in vitro analyses further suggest that chronic and high exposure to GLP-1 may impair normal muscle cell differentiation and function by disrupting intracellular energy transporter (GLUT-4) translocation and mitochondrial function [88]
[1] Current evidence does not support pancreatic cancer as an established risk
doi: 10.1371/journal.pone.0118436 19 LyJ.LagmanM.SaingT.SinghM
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