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Presented for research literature review only Weller PF et al

As an example, pharmacological and genetic inhibition of neutral sphingomyelinase (nSMase)using either GW4869 or siRNA targeting nSMase2has been shown to reduce exosome release 39

This finding derives from in silico analysis of gene expression databases rather than a single controlled experimental study, and should be interpreted as hypothesis-generating rather than definitive