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This ratio of GSH:GSSG is maintained by the action of the enzyme GSSG reductase (also known as glutathione reductase) which requires NADPH+ as the reducing cofactor
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A random-effects model was used due to significant heterogeneity (I 2 = 72.7%, Q = 17.96, P = 0.003)
Neuroinflammation is primarily caused by astrocyte and microglial activation and proliferation, activation, and translocation of transcription factors such as NF-B, and increased production of cytotoxic cytokines such as TNF- and IL-1 (Afshin-Majd et al
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