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So, while the overall weight loss percentage can vary, its evident that semaglutide-based medication leads to greater weight loss results than liraglutide-based medication
Heterogeneity in study populations, with variability in baseline BMI, age and obesity-related complication among trial participants, may influence treatment effects
Equilibrium dissociation constants (KD) were calculated using Octet Data Analysis Software v11.0 (Sartorius)
We included peer-reviewed randomized controlled trials, meta-analyses, and high-quality narrative or systematic reviews written in English that evaluated the effects of GLP-1 receptor agonists (liraglutide, semaglutide, or related analogues), as well as dual GIP/GLP-1 receptor agonists (such as tirzepatide), exercise training, or their combination on weight loss, body composition, metabolic, or cardiovascular outcomes in adults with obesity or type 2 diabetes
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