Candida's acetaldehyde impairs mitochondrial ATP production by blocking pyruvate dehydrogenase, the enzyme that converts glucose to cellular energy producing fatigue that sleep cannot resolve
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Mouse and human studies have found that intranasal insulin reduces central nervous system inflammation and improves cognition by reducing proinflammatory cytokine levels and oxidative stress, and boosting antioxidant levels and mitochondrial functioning
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Effects of melatonin supplementation on hormonal, inflammatory, genetic, and oxidative stress parameters in women with polycystic ovary syndrome
DeLeve LD, Kaplowitz N (1991) Glutathione metabolism and its role in hepatotoxicity