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The SUSTAIN-6 trial (semaglutide) and SURPASS-4 trial (tirzepatide) both demonstrated cardiovascular benefit in type 2 diabetes populations, suggesting that when appropriately prescribed, GLP-1 medications carry favorable risk-benefit profiles for metabolic health

While mild fatigue during the initial adjustment period may be manageable with dietary modifications, certain presentations of weakness warrant prompt medical evaluation to rule out serious complications

If you have a fat malabsorption disorder or follow a low fat diet, you may be at an increased risk of vitamin E deficiency

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