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If finalized by the FDA, this would allow licensed pharmacies to compound them again under a physicians prescription

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Before starting Establish baseline ALT, AST, and GGT levels 4-8 weeks Check for early changes Every 3 months Monitor ongoing response during weight loss Maintenance Test every 6 months If you have pre-existing fatty liver or insulin resistance, more frequent testing helps track improvement

[1] [2] Routine consultation with a healthcare provider is appropriate when: Bloating persists beyond 2-3 weeks despite dietary modifications and dose stabilization Symptoms significantly impair quality of life or daily functioning Bloating is accompanied by persistent nausea, early satiety, or regurgitation, which may suggest severe gastroparesis New or worsening heartburn or reflux symptoms develop There is concern about medication interactions or the need for dose adjustment Healthcare providers should evaluate for potential complications of tirzepatide therapy, including acute pancreatitis (characterized by severe epigastric pain radiating to the back, nausea, and elevated lipase levels) and severe gastroparesis

Changes in vision require prompt attention, particularly if you have diabetes, as semaglutide has been associated with worsening of diabetic retinopathy in some patients with type 2 diabetes, as noted in the SmPC

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