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European Journal of Clinical Pharmacology, 1992

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For each reaction, 500 ng of recombinant LET7 or its mutant derivatives were added to 50 l of reaction buffer (0.5 mM MnCl 2 , 20 mM Tris-HCl, pH 7.4, 1 mM EDTA, 1 mM EGTA, 0.1% -mercaptoethanol and 0.1% ethanol) and preincubated at 30 C for 1 min

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they may adjust dose or frequency or recheck vitamin levels as needed

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