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To identify the molecular changes that result in elevated striatal dopamine levels, the group analysed the transcriptome of the impacted neurons using RNA sequencing from our previously optimised approach
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The selectivity of FOXO4-DRI for senescent over non-senescent cells is mechanistically grounded: FOXO4 is expressed at low levels in most non-senescent adult cells, but is strongly upregulated in senescent cells
Both belong to a new generation of injectable peptide-based therapies that work by targeting multiple hormonal pathways simultaneously, offering potentially greater metabolic benefits than earlier single-receptor agents
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