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As in many other cancers, HCC progression is characterized by EMT with loss of epithelial markers (e.g., E-cadherin, ZO-1, Cytokeratin) and gain of mesenchymal markers (e.g., Vimentin, TWIST1, ZEB1, CD44, SNAI1, SNAI2) 38

Although the identified studies were typically small and mostly observational, they highlight the potential role of GLP-1 receptor agonists in the management of HS, John Barbieri, MD, MBA, assistant professor at Harvard Medical School and director of the advanced acne therapeutics clinic at Brigham and Womens Hospital, told Healio

The benefit of topical application is that it delivers the nutrient directly to the area of concern