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The FDA approves medications to be used according to manufacturers exact instructions
improvements in energy, body composition, and how your clothes fit are also meaningful signs of progress
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Metformin in addition to lifestyle intervention has been used in PCOS over the past few decades (27), and should be considered irrespective of glucose homeostasis in all women with PCOS with BMI 25 kg/m2, because of its expected beneficial effects on metabolic outcomes (28)
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That makes the two a clean structural pair for isolating the modifications effect
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