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The medications pharmacokinetics allow for once-weekly dosing, and research continues to evaluate long-term cardiovascular outcomes

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[1] [4] Whilst these medications are generally well-tolerated and effective, patients and healthcare professionals have raised concerns about potential effects on mood and emotional wellbeing

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It is a common form of heart failure in patients with obesity, hypertension, and metabolic syndrome, and it has become a recognized clinical target for incretin-based therapy following the STEP-HFpEF trial (semaglutide in HFpEF with obesity) and the SUMMIT trial (tirzepatide in obesity-related HFpEF)