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In cases where critical illness is accompanied by thyrotoxicosis, this comorbidity prevents the down-regulation of thyroid function
doi: 10.3389/fcimb.2025.1714998 Received 28 September 2025 Revised 11 November 2025 Accepted 17 November 2025 Published 01 December 2025 Volume 15 - 2025 Edited by Manmohan Kumar, The University of Texas Health Science Center at San Antonio, United States Reviewed by Yangyang He, The University of Texas Health Science Center at San Antonio, United States Raj Priya, University Bloomington, United States Updates Copyright 2025 Yang, Zeng, Liu and Huang
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In naturally aged mice, FOXO4-DRI improved the testicular microenvironment and alleviated age-related testosterone secretion insufficiency with decreased p53, p21, and p16 protein levels in treated testes compared to aged controls
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