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Creatine monohydrate is one of the most researched and effective sports supplements, known for its ability to increase phosphocreatine stores in muscles
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Despite the progress made in conventional prodrug strategies, their clinical application has been greatly restricted by certain flaws
Laminar flow on endothelial cells suppresses eNOS O-GlcNAcylation to promote eNOS activity
at high doses, it overwhelms and glucuronidation/CYP2E1 take over) Bile acids Catecholamines (dopamine, norepinephrine, epinephrine) Cholesterol DHEA and steroid hormones Estrogens Minoxidil (requires sulfation for activation) Thyroid hormones Sulfation is not always detoxifying
A widely cited study by Kraus and colleagues used genetic knockdown in mice
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