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Interestingly, the paracrine versus endocrine sources of IGF-1 can impact its function
The same protein-first, scheduled-eating strategy that applies to GLP-1 alone applies to the combination, but with extra attention to caloric floor (1200-1400 for women, 1500-1800 for men) and protein intake (1.2-1.6 g per kg body weight daily)
Thus, the cytokines released from these reactions promote tumor growth, migration, and invasion into blood vessels (6)
Better access to innovative drugs is expanding treatment options
The time to steady state is clinically relevant because maximum therapeutic effects on glycemic control and weight loss are not fully realized until this equilibrium is reached
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