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A recommendation for early termination due to safety reasons will be considered by the independent DSMB if the Haybittle-Peto boundary (p=0.001, Z=3) at a given interim analysis is crossed

That is worth repeating

Current scientific literature emphasizes early-stage model observations, and interpretations remain exploratory

Next generation of obesity drugs - combination By the time Novo Nordisk's scientists had unlocked the potential of GLP-1 for obesity, a number of other researchers elsewhere were beginning to also explore its potential

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Relation between acute kidney injury and multiple-organ failure: the chicken and the egg question