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Presented for research literature review only Khodaverdian S et al

The FDA found no clinical evidence supporting wound healing, no adequate toxicology, uncertain product identity and a potential immunogenicity risk with injection

For preclinical tissue models, stronger evidence would require standardized injury models, blinded outcome assessment, histological confirmation, functional endpoints, and comparison against appropriate positive and negative controls

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The Akt (Protein Kinase B) and eNOS (endothelial Nitric Oxide Synthase) components of this pathway are well-established mediators of angiogenesis and vascular repair