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An example is B003-2A, a recently developed IGF-1R anti-idiotypic antibody antagonist, which abrogated the IGF-1R-mediated proliferation of ovarian cancer cells in vivo and in vitro and overcame resistance to cisplatin in ovarian cancer cell lines (64, 74)

271 (Pt 1): E808E813

Reprogramming of cancer cell energetics is fundamental to tumour progression and spread 6,7 but is also critically linked to therapeutic efficacy 8

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