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The expression of M2 and M3 receptors was downregulated due to the pharmacological actions of daidzin hence relieving the bladder dysfunction in IC (Wu et al., 2018)
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The Lancet (2021) This Phase 2 dose-finding trial randomized adults with overweight or obesity without diabetes to cagrilintide at doses from 0.3 to 4.5 mg weekly, placebo, or liraglutide 3.0 mg daily as an active comparator across 57 sites in 10 countries
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This approach mirrors strategies used with other peptide therapies to optimize tolerability
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