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The ongoing SURPASS-CVOT and SYNCHRONIZE-CVOT trials will expand this landscape, testing the cardiovascular efficacy of dual agonists like tirzepatide and survodutide in broader populations, including those with obesity and established cardiovascular risk (ClinicalTrials.gov identifiers: NCT04255433, NCT05556512)

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Even the aforementioned systematic review calls for further investigation

Effect of Aerobic or Resistance Exercise, or Both, on Intermuscular and Visceral Fat and Physical and Metabolic Function in Older Adults With Obesity While Dieting

The medication requires consistent daily dosing to maintain effect

Taken together, these data suggest that GLP-1R agonists need to engage multiple extrahypothalamic and hypothalamic populations simultaneously to exert their inhibitory effects on food intake and body weight, at least in the chronic setting