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26,43,44 The enzymes UGT (glucouronidation), SULT, CYP 450, GST, N -deacetylase (deacetylation), NAT2 (deacetylation), and fatty acid amide hydrolase are involved in APAP metabolism and have been shown to be related to both hepatic and nephrotoxic effects of the analgesic medication
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In some people, particularly those taking anticonvulsants, this conversion can theoretically decrease the effectiveness of the medications and potentially increase the risk of seizures
GRAS food ingredient note AOD-9604 was self-affirmed as Generally Recognized As Safe (GRAS) by an industry expert panel for limited food-ingredient use based on the Phase 1 and Phase 2 safety data
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