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Recent evidence shows that PBMs and manufacturers negotiate rebates that are contingent on excluding lower-cost competitor drugs from the formulary, placing these drugs on a high cost-sharing tier, or applying utilization management rules

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C-GSHf_Fwd 5-GGGCGGAATTTACGTAGCTTAAGT-3;C-GSHf_Rev List of other constructs in the manuscript PMXS_IRES_BLAST_Hu_SLC25A39

The 2.5 mg dose is a starter dose intended for treatment initiation and should be increased after 4 weeks as tolerated, as it is not intended for long-term glycemic control

The most consistent and durable outcomes occur after two to three complete 3-month protocols