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Intracellularly, testosterone is converted into a more potent 5-reduced metabolite of testosterone, 5-dihydrotestosterone (DHT), which promotes the growth and survival of prostate cells

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doi:10.5664/jcsm.9392 Wang R, Dong Y, Weng J, et al

The article argues those metrics help separate a placebo effect from genuine physiologic change and give the provider something concrete to act on

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3B and D), thus stroma development, which might explain the higher PDAC aggressiveness in dysmetabolic patients partly due to absence of tumor T lymphocyte infiltration