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[62] [63] The mechanism of action is straightforward: the hydroxycobalamin hydroxide ligand is displaced by the toxic cyanide ion, and the resulting non-toxic cyanocobalamin is excreted in urine

Important Context: AOD-9604 completed six randomized, double-blind, placebo-controlled trials involving over 900 participants

In conclusion, vitamin B12 deficiency is a common health issue that can have severe negative effects on our bodies

When to increase dose Consider increasing if: Minimal response after 4-6 weeks at current dose No side effects at current dose Current dose below the higher end of recommended range Goals not being met with conservative approach Increase gradually, typically by 25-50% at a time

AOD-9604 is supplied as a lyophilised powder and is reconstituted prior to use with sterile bacteriostatic water

Researchers also found that decreasing NNMT caused a 47% reduction in the mices fat mass