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1961 adults with obesity (mean BMI 37.9) but without type-2 diabetes were randomised to placebo or semaglutide 2.4 mg weekly for 68 weeks

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Renal or hepatic impairment does not significantly alter elimination times, and no dose adjustments are required based on kidney or liver function

The proliferation of unauthorized manufacturers and online sellers can cause confusion among consumers, fuel market noise, and undermine trust in legitimate therapies

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