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However, their use in this context is regulated and reserved for very specific situations , particularly for people with a high body mass index (BMI) associated with health problems, such as type 2 diabetes, hypertension or cardiovascular disease

[2] [5] The additional GIP receptor agonism is thought to complement these effects, with proposed (though not fully established in humans) benefits for insulin sensitivity and weight reduction

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Global burden of cardiovascular diseases and risk factors, 19902019: update from the GBD 2019 study