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The National Heart, Lung, and Blood Institute describes cognitive behavioral therapy for insomnia, or CBT-I, as the usual first treatment for long-term insomnia

Subjective improvement in pain, function, and activity tolerance provides the primary effectiveness signal

In some embodiments, the isotonic agent is sodium chloride

Study of the activity of glutathione-peroxidase, glutathione-transferase, and [PMID: 12826156] Laboratory literature summary: Study of the activity of glutathione-peroxidase, glutathione-transferase, and glutathione-reductase in renal transplants

The 2-adrenoceptor agonist dexmedetomidine converges on an endogenous sleep-promoting pathway to exert its sedative effects

Trials typically employed a structured dose-escalation pattern to manage tolerability