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This unexpected outcome likely resulted from indirect attenuation of dopaminergic signaling due to combined PDE10A inhibition and D 2 receptor blockade from antipsychotics, producing excessive suppression of dopaminergic signals

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Changes in normal methylation patterns have been linked to a range of diseases, including cancer, cardiovascular disease, and neurological disorders, highlighting its importance in both health and disease

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Ferreira et al., 2021