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Dulaglutide uses a different approach, fusing GLP-1 with an immunoglobulin fragment (Fc-fusion) to extend its duration of action
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However, once diagnosed it presents a difficult management problem in patients suffering from pernicious anemia, as there is no substitute
DeL, HY, KT, MB and JR added critical intellectual content to the manuscript and can be considered experts on the topic
Nature 443 , 709712 (2006)
Excessive adipose tissue, especially in visceral depots, induces a state of chronic low-grade inflammation and dysregulated secretion of adipokines, impairing insulin signaling pathways and exacerbating insulin resistance
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