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Some manufacturers may combine semaglutide with vitamin B12 to help reduce the risk of vitamin B12 deficiency, which can occur in people taking semaglutide or other medications that fall into the same class of drugs
The standard protocol begins with 0.25 mg once weekly for four weeks, increasing to 0.5 mg, with further increases to 1 mg or 2 mg only if needed and tolerated
But this bias can cause harm
HbA1c reductions are typically in the 1.0% to 1.4% range with oral semaglutide versus 1.5% to 1.8% with injectable
With semaglutide, these often include nausea, diarrhea, and constipation
The dual action appears to create additive benefits
