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In murine models, acute inflammation peaks by day 5, with monocyte infiltration and upregulation of proinflammatory cytokines

10.1016/j.bcp.2020.114187 Biochem

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The clinical picture: Providers are connecting persistent fatigue and skin deterioration (dull, gray, acne) in months 36 on GLP-1 to this depletion

Weight regain after discontinuation is also a well-documented concern, which makes having a post-treatment plan just as important as the treatment itself