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Long-term human safety profile requires further validation
5-Amino-1MQ, as an NNMT inhibitor, alters a pathway involved in NAD+ and methylation balance, and its long-term effects in people are simply unstudied
22 Interleukin-6, vascular endothelial growth factor, insulin-like growth factor-1 and Annexin V assay kit were from Life Technologies (Carlsbad, CA, USA)
The Spirulina cell includes a wide variety of bioactive substances associated with phycocompounds like phenolic compounds, e.g., flavonoids, isoflavonoids, stilbenes, which include curcumin and curcuminoid derivatives, carotenoid especially lycopene as well as polyterpenes, alkaloids, saponins, steroids
Summary Interpretation The most defensible interpretation is that 5-Amino-1MQ is a small-molecule NNMT inhibitor that has been used in published preclinical research models without prominent severe acute toxicological signals described in the cited preclinical model reports under their specific tested conditions
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