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Significant weight loss can impact [the hormonal balance of estrogen and progesterone], leading to menstrual irregularities like missed periods, heavy or light periods, and irregular periods. This is especially true when your estrogen levels change due to weight loss, says Dr
This has been demonstrated in the NOD.H2 h4 mouse model of autoimmune thyroiditis where iodide treatment enhanced the transcription of intercellular adhesion molecule-1 triggered by reactive oxygen species and, in particular, by hydrogen peroxide generated in the thyrocyte for the organification of iodine ( Reference Burek and Talor 26 , Reference Sharma, Traore and Trush 27 )
The timeline for losing weight can depend on several factors, including diet and exercise
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Excess body fat, particularly visceral fat, converts testosterone to estrogen through a process called aromatization
It signals fullness through GLP-1 receptors in the hypothalamus and brainstem, which patients describe as the quieting of food noise, connected to the psychology around overeating and resultant weight gain
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