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S., Klawans, H
reported that more extreme changes in serum metabolite profiles from days 1 to 4 after severe TBI corresponded to unfavorable clinical outcomes and that serum metabolites on day 4 could better predict outcomes than serum metabolites collected on day 1 [27]
That pharmacokinetic profile is why a preexercise dose is usually recommended about 30 to 60 minutes before activity if your aim is acute availability
By analogy, intratympanic PRP, Autologous Conditioned Serum, or stem cell injections should likewise achieve much higher local levels of therapeutic factors, with far lower systemic exposure and side effects
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