From a pharmacological approach, mitochondrial Mn-SOD has been found to be not inactivated by NO (Mart et al., 2012), although this enzyme binds and stimulates NO decay under both anaerobic and aerobic conditions (Filipovic et al., 2007)
Hepatology 1998
(40), found increased Fe2+ content in H9C2 cells treated with high glucose
Results FoB and MZB exhibit distinct glutathione-based redox dependencies To dissect the redox state of MZB and FoB in relation to the main antioxidant GSH, we studied the expression of Gclc , which is necessary for GSH synthesis 24 , in isolated MZB and FoB from spleens of C57BL/6J (B6 or wild-type) mice
This method has the advantage of rapidly obtaining high-purity products and is suitable for small-scale or medium-scale syntheses
For example, mtDNA copy number correlates with OXPHOS activity and may indicate potential sensitivity to mitochondrial inhibitors [133]