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GLP-1 receptor agonists were originally approved for the treatment of type 2 diabetes, though given the prevalence of GLP-1 receptors in various peripheral tissues, more recent studies have started to look at additional etiologies for which GLP-1 agonists could be a feasible therapeutic option, including MASLD
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These findings indicate that GLP-1R activation specifically inhibits GSDMD-mediated microglial pyroptosis, a finding consistently replicated in subsequent in vitro experiments (Song et al., 2022)
10.1093/nar/gkae236 18 FurmanB
Metformin Metformin is one of the few medications considered generally safe during breastfeeding that also supports weight management
doi:10.5665/sleep.3298
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