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Zhou L, Bryant CD, Loudon A, Palmer AA, Vitaterna MH, Turek FW

[4] NAD + and SAM changes are not automatically harmful, and they should not be interpreted as toxicological findings by themselves

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Studies on -synuclein demonstrate that methionine residues near the N-terminus are more susceptible to copper-mediated oxidation than internal residues, with Met1 substitution decreasing Cu-peptide reduction potential by approximately 80 mV