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Higher concentrations mean more active ingredient deposited in a smaller tissue area, which increases the probability and severity of local irritation

A random-effects model was chosen because the trials differ in the populations included or in the follow-up

Superoxide dismutase activity was found to be significantly higher in the ectopic endometrium than in eutopic endometrium, and a positive correlation was seen between malondialdehyde levels and plasma 17-beta estradiol levels