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Our findings raise the possibility of using PEPITEM derived peptides for the treatment of psoriasis." "This study also raises the interesting possibility that PEPITEM derived peptides could be used in combination with other psoriasis therapies, allowing lower dosing for longer durations, for example, a 'steroid sparing' approach, to reduce the side effects associated with prolonged use of such agents." Further investigation showed both the whole PEPITEM molecule and the tripeptide sequences are powerful regulators for the synthesis of signalling molecules that promote inflammation, leading to the recruitment of immune cells and proliferation of other cell types in skin tissue involved in disease, with some tripeptide sequences showing an order of magnitude increase in efficacy compared to the parent PEPITEM sequence
Cycling represents common practice in the peptide community, alternating periods of use with breaks
Subsequent crystallographic and functional studies established the molecular basis for this thiol-based redox-switch
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Potential benefits of MOTS-c: Improved insulin sensitivity Better glucose control Increased exercise capacity Enhanced mitochondrial function Improved metabolic flexibility Unlike Semaglutide or Tirzepatide, MOTS-c does not primarily work by reducing appetite
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