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Most treatment discontinuations were due to gastrointestinal AE and occurred during the rapid escalation phase this may be mitigated with more gradual dose escalation at phase 3 trials
Back Unger, RH (1 Feb 1975) 'Diabetes and the Alpha cell', The Banting Memorial Lecture, Diabetes , 25, 2
(2013) 8:e57610
During oxidative stress, Nrf2 translocates into the nucleus to regulate the transcription and expression of antioxidant response elements (ARE), activating the intracellular antioxidant enzyme system to eliminate excess ROS and bolster the cells antioxidant capacity (Suzuki and Yamamoto, 2015)
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Vitamin C contributes antioxidant protection and supports skin radiance, while Vitamin E helps nourish and protect the skin
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