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Los grupos tiol se mantienen en un estado reducido a una concentracin de aproximadamente ~ 5 mM en clulas animales
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doi: 10.1186/s12885-018-5050-x 311
Clearly, mAb1-bound GCGR is unable to assume the closed conformation observed in the Fab7F38GLP-1R structure
This is a genuinely novel clinical phenomenon
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