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This is concerning because different "normal" but suboptimal micronutrient levels (also called marginal deficiencies or inadequacies) have been associated with various chronic health conditions, including cardiovascular disease, cancers, and stroke
In fact, an adult may take doses up to about 2400 mg/day of ALA without severe harmful effects in the short term, although higher doses do not necessarily confer additional benefit
Initial applications favored topical and local repair
Beyond these, in the tubular injury of DKD, autophagy determines cellular susceptibility to apoptosis, pyroptosis and ferroptosis (79, 225)
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