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Increased body temperature : High serotonin levels cause hyperthermia, a dangerous rise in body temperature that requires immediate medical intervention, according to a study by Petroianu GA

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The primary role of GSTs is to detoxify xenobiotics by catalyzing the nucleophilic attack by GSH on electrophilic carbon, sulfur, or nitrogen atoms of said nonpolar xenobiotic substrates, thereby preventing their interaction with crucial cellular proteins and nucleic acids

On May 1, 2025, Eli Lilly announced that it withdrew its FDA application for Zepbound (tirzepatide) for the treatment of HFpEF in patients with obesity, stating that the FDA requires an additional confirmatory trial to support the application

J., Abdullah, S