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AR shuttles between the cytoplasm and nucleus and its phosphorylation state has an impact on subcellular localization (PMID: 16282370)
Shanmugham M, Bellanger S, Leo CH
Outcomes and assessments Results for the primary and secondary outcomes were published 19
The additional GIP activity enhances insulinotropic effects and may amplify weight loss via both central and peripheral pathways not fully replicated by GLP-1 agonism alone 5
When thyroid hormone levels are too low, metabolism can slow, energy levels can drop, and the body may burn fewer calories than expected, making it easier to gain weight and harder to lose it
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