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Weeks 1-4: 2mg once weekly Weeks 5-8: 4mg once weekly Weeks 9-12: 8mg once weekly Week 13 onward: 12mg once weekly (maintenance) Total escalation time spans 12 weeks, slower than some competitors but necessary given the triple-receptor mechanism

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Semaglutide 2.4 mg once a week for adults with overweight or obesity and type 2 diabetes (STEP 2)

This is the most critical area of change for practitioners and patients in 2026

In these patients, doctors may monitor blood sugar, HbA1c, kidney function, eye health, and the risk of hypoglycaemia, especially if insulin or sulfonylureas are also used

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