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Clinical trial data from large cardiovascular outcome studiesincluding LEADER (liraglutide), SUSTAIN-6 (semaglutide), and REWIND (dulaglutide)have not demonstrated increased fracture risk among patients taking GLP-1 receptor agonists compared with placebo
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Article updated 12/17/2025 to reflect recent FDA communications, regulatory clarifications and clinical context related to GLP-1 medications
Statistical analysis Statistical analysis was performed with SPSS 21.0 for Windows (IBM, Armonk, NY, USA)
Read the full study: Metabolic studies of a synthetic lipolytic domain (AOD9604) of human growth hormone (Horm Res 2000)