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DES(1-3) IGF-1 is a truncated variant missing the first three N-terminal amino acids (Gly-Pro-Glu), which also reduces IGFBP binding but through a different structural mechanism removal of the N-terminal tripeptide rather than charge substitution

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Valence spectra further confirm that the average valence state of Ru in Ru SA+AC is + 3.72 (Fig

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The decline was also not evenly spread, as the largest drops were seen in men and people living with joint or muscle pain