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The compartments are : The intestine that absorbs the rapamycin and send it into the blood The blood is the central compartment that gets the rapamycin from the intestine and has bidirectional exchanges with the organs as well as some elimination (by metabolization) The organs which exchange Rapamycin with the blood (both ways) Here is that model with the differential equations fitted to the paper data for rapamycin + fat (dots) [image] As you can see the fit is very good which shows that the 3 compartment model is good enough
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The active ingredient is identical, so the pharmacological interactions with alcohol are the same
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Still, changes in DNA have been identified that could be meaningful in the identification and design of the next therapeutic strategies
